Publications

Publications
  1. Miñana, J.B., Gómez-Cambronero, L.G., Lloret, A., Pallardó, F.V., del Olmo, J., Escudero, A., Rodrigo J.M., Pellín A., Viña, J.R., Viña, J. and Sastre, J. (2002) Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology 35 (5): 1205-14. doi: 10.1053/jhep.2002.32969.
  2. Pereda, J., Sabater, L., Cassinello, N., Gómez-Cambronero, L., Closa, D., Folch, E., Aparisi, L., Calvete, J., Cerdá, M., Lledó S., Viña, J., Sastre, J. (2004) Effect of simultaneous inhibition of TNF-a production and xanthine oxidase in experimental acute pancreatitis. The role of mitogen activated protein kinases. Ann. Surg. A 240:108-16. DOI: 10.1097/01.sla.0000129343.47774.89.
  3. Moreno ML, Escobar J, Izquierdo-Álvarez A, Gil A, Pérez S, Pereda J, Zapico I, Vento M, Sabater L, Marina A, Martínez-Ruiz A, Sastre J. Disulfide stress: a novel type of oxidative stress in acute pancreatitis. Free Radic Biol Med 2014;70:265-277. doi:10.1016/j.freeradbiomed.2014.01.009
  4. Pérez S, Pereda J, Sabater L, Sastre J*. Redox signaling in acute pancreatitis. Redox Biol. 2015;5:1-14. DOI: 10.1016/j.redox.2015.01.014
  5. Pérez S, Taléns-Visconti R, Rius-Pérez S, Finamor I, Sastre J. Redox signaling in the gastrointestinal tract. Free Radic Biol Med. 2017; 104:75-103. doi: 10.1016/j.freeradbiomed.2016.12.048
  6. Pérez S, Rius-Pérez S, Finamor I, Martí-Andrés P, Prieto I, García R, Monsalve M, Sastre J*. Obesity causes PGC-1α deficiency in the pancreas leading to marked IL-6 upregulation via NF-κB in acute pancreatitis. J Pathol. 2019;247(1):48-59. DOI: 10.1002/path.5166. This work received an editorial comment published in the Journal of Pathology. (Diakopoulos, K., and Algül, H. New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis. J Pathol. 2019;248(1):6-8. doi: 10.1002/path.5220.)
  7. Pérez S, Finamor I, Martí-Andrés P, Pereda J, Campos A, Domingues R, Haj F, Sabater L, de-Madaria E, Sastre J*. Role of obesity in the release of extracellular nucleosomes in acute pancreatitis. A clinical and experimental study. Int. J. Obes. 2019;43(1):158-168. DOI: 10.1038/s41366-018-0073-6
  8. Rius-Pérez S, Pérez S, Torres-Cuevas I, Martí-Andrés P, Taléns-Visconti R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L, Corrales F, Sastre J. Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase. Redox Biol. 2020;28:101324. DOI: 10.1016/j.redox.2019.101324
  9. Rius-Pérez S, Pérez S, Martí-Andrés P, Monsalve M, Sastre J*. Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation. Antioxid Redox Signal. 2020; 33(3):145-165. DOI: 10.1089/ars.2019.7975
  10. Rius-Pérez S, Pérez S, Toledano MB, Sastre J. p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3. Redox Biol. 2022;56:102423. doi: 10.1016/j.redox.2022.102423
  11. Rius-Pérez S, Pérez S, Toledano MB, Sastre J. Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation. Antioxid Redox Signal. 2023;39(10-12):708-727. doi: 10.1089/ars.2022.0209.
  12. Martí-Andrés P, Finamor I, Torres-Cuevas I, Pérez S, Rius-Pérez S, Colino-Lage H, Guerrero-Gómez D, Morato E, Marina A, Michalska P, León R, Cheng Q, Jurányi EP, Borbényi-Galambos K, Millán I, Nagy P, Miranda-Vizuete A, Schmidt EE, Martínez-Ruiz A, Arnér ES*, Sastre J. TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. EMBO J. 2024. 43(13):2789-2812. doi: 10.1038/s44318-024-00117-1.
  13. Sastre J, Pérez S, Sabater L, Rius-Pérez S. Redox signalling in the pancreas in health and disease. Physiol Rev. 2025;105(2):593-650. doi: 10.1152/physrev.00044.2023.

Information

CIPROM/2024/84
DEPARTAMENTO DE FISIOLOGÍA, FACULTAD DE FARMACIA Y CIENCIAS DE LA ALIMENTACIÓN

LINEA DE INVESTIGACIÓN: GASTROENTEROLOGÍA EXPERIMENTAL

Universitat de ValènciaGeneralitat Valenciana